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This study is registered on ClinicalTrial.gov (NCT00984750) and ClinicalTrialsRegister.eu (EUDRACT 2007-005925-31)

456 In the spinal cord, the influx of neuropathic signals to the dorsal horn leads to central sensitization, characterized by increased spontaneous neuronal activity, lowered activation thresholds for peripheral stimuli, heightened responses to sub-threshold stimuli, and expansion of receptive fields

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