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Figure 10.Change from Baseline (%) in BMI in Pediatric Patients with Obesity Aged 12 Years and Older in Study 7 Observed values for patients completing each scheduled visit, and estimates with multiple imputations from retrieved dropouts (RD-MI) Figure 11.Change in BMI (%) from Baseline to Week 68 in Pediatric Patients with Obesity Aged 12 Years and Older in Study 7 Observed data from in-trial period including imputed data for missing observations (RD-MI) Effect of WEGOVY on Anthropometry and Cardiometabolic Parameters in Pediatric Patients with Obesity Aged 12 Years and Older Changes in waist circumference and cardiometabolic parameters with WEGOVY are shown in Table 14 for the study in pediatric patients aged 12 years and older

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the clinical significance over the long term requires further evaluation Injection-site reactions : Such as redness, bruising, or discomfort at the injection site Dizziness and headache Raised amylase and lipase levels : Detected on laboratory testing

Accordingly, the areas of unmet need for new treatments are reflected in the lesions that underly the hyperglycaemia, notably impaired function and number of pancreatic beta cells, insulin resistance and glucose toxicity, which are frequently aggravated by excess adiposity, abnormalities of glucagon secretion, an altered incretin response and disturbances in lipid metabolism [6]