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nevertheless, the criteria for participant selection were in accordance with the FDA and EMA guidelines for DDI clinical trials [39, 40] and the use of healthy subjects prevents the potential confounding effect of concomitant medications and co-morbidities

Heart tissue samples were weighed, homogenized with 8 times of 2.5 mM ammonium acetate in methanol, and 20 L of the extraction from each sample was used for the assay

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