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WT endometrium-recipient mice fed HFD (45% kcal from fat) showed reduced lesion incidence, numbers, and volumes, in the absence of changes in systemic ovarian steroid hormone and insulin levels, relative to those fed the control diet (CD, 17% kcal from fat)

Crichton RR, Ward RJ, Hider RC

Designing personalized therapeutic regimens that combine SIRT1 activators with complementary pathways, such as AMPK, Nrf2, or FXR, may enhance precision

This hypothesis is supported by our observation that ER-targeted LaccID was unable to catalyze DAB polymerization after cell fixation

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