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Shows Potential for Improving Heart Health I highly doubt that Tesamorelin will ever be used for directly lowering ones risk of cardiovascular disease (CVD), yet a small piece of information from one randomized clinical trial shows some hope: In this trial, Tesamorelin reduced the thickness of the left carotid intima artery, which is important when you consider that a thicker artery is one of the earliest biomarkers of CVD: The amount of lesion in the common carotid artery (CCA) has been reported to correlate to the extent of atherosclerotic lesions elsewhere in the body

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41 Similarly, Aronne et al reported that in overweight or obese individuals, most of the weight lost during tirzepatide therapy was regained after treatment discontinuation