Appl Physiol Nutr Metab 45:S218S231
Each of these nutrients has individually been shown to produce positive effects in HIV-infected individuals.33-42 In addition, antioxidant supplementation has previously been associated with a reduction in viral load23,43 and has been observed to produce a significant decrease in CD4 cell apoptosis.34 This effect was reported in 2 studies after supplementation with the antioxidant l-carnitine in both symptomatic33 and asymptomatic HIV-infected patients.34 The mechanism of action of apoptosis in HIV-infected CD4 cells is believed to result from the effect of HIV itself and from concomitant antioxidant imbalances in host cells.44-46 A correction of these imbalances, leading to a subsequent decrease in the apoptosis rate of CD4 lymphocytes, may be partially responsible for the increases in CD4 cell counts observed in our study
Nat Med 23:859868
Ferroptotic cell death is associated with various pathological conditions, including acute kidney injury, hepatocellular degeneration and hemochromatosis, traumatic brain injury, neurodegeneration and carcinogenesis 32,33,34,35,36,37
statistical significance in f and h was determined by one-way ANOVA followed by Bonferroni post-hoc analysis
