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In a rat model of adjuvant-induced arthritis, the combination of metformin (200 mg/kg/day) and omega-3 (300 mg/kg/day) showed efficacy comparable to methotrexate (2 mg/kg/week) in ameliorating disease activity, with significant reductions in arthritic scores, paw swelling, and serum TNF- and IL-1 after 4 weeks (252)

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explored the joining between p53 and ALDH in cancer development and discovered greater diversity in ALDH isoform expression in p53-inactivated (p53WT) cases due to the HPV16 E6 oncogene in HNSCC patients

Materials and Methods X