Similar content being viewed by others Introduction Anxiety and depression have become the leading mental health challenges worldwide, affecting millions of people each year, with a substantial increase following the COVID-19 pandemic [1]
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Furthermore, tacrolimus has also been reported to act on melanocytes and may improve vitiligo through various enhancements, such as increasing matrix metalloproteinases (MMPs)-2/9 expression and promoting melanocyte migration40, increasing the expression of stem cell factor (SCF)/MMP-9 from keratinocytes, promoting the proliferation and migration of melanocytes and melanoblasts41, increasing c-KIT expression and promoting melanin synthesis in melanoma cell lines42, and facilitating melanosome maturation and transportation to keratinocytes43
