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For instance, it remains undefined whether Gd-IgA1 directly binds to mesangial cell receptors to activate the PPARFABP1 axis, or if indirect signals (e.g., inflammatory cytokines and complement activationhallmarks of IgA nephropathy) are required

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Subjects were 54 healthy adults (41 females/13 males), 28-72 years of age (mean=46.6 years)