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Mechanistic studies further propose that increased intestinal permeability (leaky gut) may allow bacterial metabolites and endotoxinssuch as lipopolysaccharideto enter the circulation and activate systemic and neuroinflammatory pathways ( In a Chd8 deficient mouse model, excessive epithelial proliferation and microvillus abnormalities were linked to BBB dysfunction and microglial activation

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An Approach with Real Impact Recently, Oshi analyzed the subset of its patients on GLP-1s to uncover the impact of providing multidisciplinary support to GLP-1 patients

Lapointe J, Kimmins S, Maclaren LA, Bilodeau JF