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All raw RNA-seq data of mouse oocytes generated in this study have been deposited in the Genome Sequence Archive (GSA) database under accession code CRA022577 and are publicly accessible at The targeted metabolomics data generated by LC-MS/MS have been deposited in the MetaboLights repository under accession number MTBLS13957 and are publicly accessible at The LiP-SMap proteomics raw data have been deposited in the PRIDE repository under the ProteomeXchange dataset identifier PXD075265 and are publicly available at Source data are provided with this paper