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The role of the circadian system in the etiology of depression

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doi: 10.1016/s0300-483x(01)00472-3

Clinical Safety Profile Comprehensive safety analysis from clinical trials demonstrates excellent tolerability of pure Himalayan berberis extracts, with adverse events occurring in less than 3% of participants and typically limited to mild gastrointestinal adjustments during the initial adaptation period

A large randomized trial in older adults found no effect of EPA and DHA on cognitive function, and the broader trial record shows little benefit in cognitively healthy people or in established Alzheimers, with a possible signal in early cognitive impairment and in people who do not carry APOE4