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The gap between demonstrating a mechanism in cell culture and demonstrating meaningful health outcomes from an oral supplement is enormous

Endocrinologist Ania Jastreboff tells her patients that GLP-1 medications may change their desire to eat

Biomaterials (2021) 275:120944

HOLST: Oh it's interesting that in people with diabetes we have either too little insulin or too little insulin action, and usually too much glucagon, and that's one of the reasons that the blood glucose goes high, that they have too much glucagon at the wrong time

GLP-1 medications are not approved as a replacement for insulin in type 1 diabetes