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doi:10.2165/11599200-00000000000000 [DOI] [PMC free article] [PubMed] [Google Scholar] 20.Xu Q, Pan J, Yu J, et al

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With these peptides, the pituitary still responds to the body's own signals, which is intended to keep release within a natural range and rhythm

However, a definitive conclusion on the actual role of IGF-1 in the coordinated maintenance of normal musculoskeletal function has been elusive as most of these promoters have been found to also be active to some degree in muscle