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Although the authors have not been able to elucidate the mechanism of anaphylaxis, they suggest that the additives used to stabilise the amino acids, such as sulphites, butylated hydroxyanisole, butylated hydroxytoluene, and olysorbate emulsifier, may be the cause of the symptoms [120]

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On the other hand, aquaporin 4 and the SWELL1 chloride channel (LRRC8A) accumulate at the cell rear mediating cell shrinkage [163]

Whether discontinuation due to adverse events has affected the statistical analysis of weight regain still required further research for support

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