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Common Dehydration Symptoms on GLP-1 Medications Many users attribute these symptoms to the medication itself, when they're actually signs of electrolyte depletion: Persistent fatigue and brain fog Dizziness or lightheadedness when standing Muscle cramps or weakness Headaches (especially afternoon crashes) Increased nausea (dehydration worsens GI symptoms) Dry mouth despite drinking water Dark yellow urine or infrequent urination Heart palpitations or irregular heartbeat If you're experiencing three or more of these symptoms, electrolyte deficiency is likely contributingand potentially amplifying your GLP-1 side effects