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Data extraction was conducted independently by two reviewers using a standardized data collection form, capturing details such as study design, sample size, participant characteristics, GSH dosage and duration, and reported outcomes

However, as with any medical intervention, its crucial for individuals to consult with their healthcare providers before initiating B12 supplementation

Regular follow-up and adjustments of the treatment plan are necessary to achieve the best results with minimal side effects

Measurements of energy expenditure and locomotor activity HFD-induced obese C57BL/6J male mice were placed in individual small acryl calorimeter chambers with free access to HFD and water, and respiratory gas (O 2 and CO 2 ) were measured every 5 min for each individual mouse by indirect calorimetry system connected to mass spectrometer (Arco2000, ArcoSystem, Chiba, Japan)

Avoid touching stoppers with hands or unsterile tools