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Patients with a personal or family history of breast cancer should use choline supplementation cautiously, as some observational studies suggest high-dose choline intake correlates with increased breast cancer risk in genetically susceptible populations

1 2 US3091569A, Sheffner AL, "Mucolytic-nu-acylated sulfhydryl compositions and process for treating animal mucus", issued 28 May 1963 Archived 6 August 2024 at the Wayback Machine US patent 3091569, Sheffner AL, "Mucolytic- N -acylated sulfhydryl compositions and process for treating animal mucus", published 28 May 1963, issued 28 May 1963, assigned to Mead Johnson & Co and Mead Johnson & Company Archived 30 June 2024 at the Wayback Machine The selection and use of essential medicines 2023: web annex A: World Health Organization model list of essential medicines: 23rd list (2023)

However, emerging data and mechanistic plausibility suggest that certain populations may be at higher risk of suboptimal intake or depletion, particularly with prolonged therapy, rapid weight loss, restricted dietary variety or pre-existing marginal nutrient status

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