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Importantly, it enabled discrimination between human-specific and animal-specific toxicities, such as those induced by bosentan (an endothelin receptor antagonist with known dose-dependent human hepatotoxicity) and fialuridine (an antiviral nucleoside analog that caused fatal human liver toxicity undetected in animals), thereby improving the extrapolation of preclinical findings to human outcomes

KDIGO 2024 Clinical Practice Guideline for the Evaluation and Management of Chronic Kidney Disease

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Hara H, Haga S, Aoyama Y, Kiriyama S

A cross-sectional study revealed that serum MDA is associated with NAFLD and NASH in men but not women, presumably due to the protection of estrogen 38