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DAMPs usually activate the innate immune response and macrophages are recruited and activated to secrete various mediators such as macrophage inhibitory protein-1, monocyte chemoattractant protein-1, and IL-8, leading to interstitial inflammation in the kidney [108]

"Outcomes of mild therapeutic hypothermia after in-hospital cardiac arrest." Neurocritical care , 16(3), (2012) 406-12

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Rofecoxib modulates multiple gene expression pathways in a clinical model of acute inflammatory pain