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The first study to demonstrate superiority over placebo was the LEADER study, in which 9,340 patients were assigned to either liraglutide or placebo

For the short-term MIA model, 120 animals were divided into seven groups: saline/vehicle group (n = 19 mice), MIA/vehicle group (n = 18), all MIA/liraglutide groups (n = 17), and dexamethasone group (n = 15)

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In clinical trials of injectable semaglutide and liraglutide, similar heart rate increases were observed but were not associated with adverse cardiovascular outcomes