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The case of levodopa degradation in PD is illustrative: scientists identified a gut bacterial tyrosine decarboxylase that was eating up patients Parkinsons medication, and they found a small-molecule inhibitor that could block this enzyme and thus prevent levodopa loss

Data Animal Data Dapagliflozin dosed directly to juvenile rats from postnatal day (PND) 21 until PND 90 at doses of 1, 15, or 75 mg/kg/day, increased kidney weights and increased the incidence of renal pelvic and tubular dilatations at all dose levels

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Schreiber R, Dautovich, N

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