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In activated T cells, flux through the oxidative PPP increases nearly 10-fold, but chemical inhibition of G6PD can markedly decrease this and, as a result, impair T cell activation and decrease production of pro-inflammatory interferon-gamma (IFN-) (55)
AstraZenecas litigation over omeprazole and its magnesium salt form (Nexium) is the textbook case: the company shifted commercial promotion to the new form ahead of generic entry on the original, extracting billions in revenue at premium pricing from patients who received brand switching without any meaningful therapeutic difference
Gen Comp Endocrinol (2010) 165:54956.10.1016/j.ygcen.2009.07.004 20 BehneDHoferTVon Berwordt-WallrabeRElgerW
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