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Comprehensive application of GSH chemical binding and enzymatic binding models The GSH chemical binding and enzymatic binding models are collectively termed the GSH binding model, enabling more accurate interpretation of relevant data in the research and development of covalent inhibitors

These medications are intended as an adjunct to a reduced-calorie diet and increased physical activity, not as standalone treatments

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In a Phase 1 randomized, double-blind clinical study targeting obese participants (NCT04478708), AMG133 demonstrated acceptable safety, tolerability, and significant dose-dependent weight loss