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The 8mg dose achieved 21.1% weight loss (matching Zepbounds efficacy) with lower side effects: 24% nausea versus 28% at 12mg, 8.4% discontinuation versus 11.2%

Where AOD 9604 directly attacks fat cells through adrenergic receptors, tirzepatide works upstream by modifying appetite signaling, insulin response, and gastric emptying

Repeatedly using the spray exposes the solution to fresh air, increasing the potential for oxidative damage to the amino acid structure

Over-diluting creates larger volumes that must be stored longer, increasing degradation exposure

However, it's important to note that comprehensive human clinical trials remain limited, and most safety and efficacy data comes from animal studies