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Although microbial-based interventions, such as probiotics, demonstrate therapeutic potentialfor instance, certain strains of Lactobacillus and Bifidobacterium have shown preliminary efficacy in alleviating depressive symptoms (281)their benefits in schizophrenia remain inconsistent and lack high-quality clinical support (282)

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Subsequent in vivo work in transected tendon and ligament models has reproduced these findings and added documentation of accelerated collagen deposition, growth-hormone receptor upregulation, and improved biomechanical recovery markers