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Based on the eligibility criteria, some patients without a genetic cause of SPIGFD may have been excluded and it is uncertain whether the results can be extrapolated to this group of patients

Certain substrates become more reactive after sulfation, a process called bioactivation

This lack of blood supply results in a deficiency of blood, nutrients, and oxygen when an injury occurs

Other diseases characterized by increased metabolism (e.g., hyperthyroidism) are associated with decreased serum cobalamin concentrations [58]

Specifically, the prefrontal regions encompassed the orbitofrontal and subcallosal cortices, while the limbic region included the amygdala and hippocampus (Supplementary Fig