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Beyond direct -cell protection, butyrate exerts indirect protective effects by modulating immune responses and promoting the differentiation of Tregs that shield pancreatic -cells from cytokine-induced damage (189, 190)
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Its deficiency causes oxidative stress that not only promotes the oxidation of proteins and deoxyribonucleic acid (DNA) but also leads to insulin resistance, dyslipidemia, inflammation, and metabolic alterations, which expose to high risk for cardiometabolic disorders due to cardiovascular and degenerative diseases especially when associated with aging
Compare this to a 10 mg/mL concentration where 0.5 mg is only 5 units, nearly impossible to measure accurately
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