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Shabto JM, Martini DJ, and Liu Y, et al (2019) Association between immune-related adverse events (irAEs) and clinical outcomes (CO) in advanced urothelial cancer patients (pts) treated with immunotherapy (IO) J Clin Oncol 37 (7_suppl) 472 64

The Role of P450 Enzymes in Detoxification and Methylation Pathways In addition to the previously discussed detoxification pathways of methylation and glutathione, P450 enzymes also play a crucial role in detoxification

Yap activation in renal proximal tubule cells drives diabetic renal interstitial fibrogenesis

Metformin therapy attenuates pro-inflammatory microglia by inhibiting nf-kappab in cuprizone demyelinating mouse model of multiple sclerosis

For example, the most commonly used treatment is N-acetylcysteine (NAC), which helps replenish glutathione in the liver, allowing it to neutralize toxic metabolites