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It is usually not clinically significant but can be bothersome

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Understanding nausea on Mounjaro Mounjaro (tirzepatide) can trigger nausea in two key ways: It slows down your stomach emptying, which means food stays in your stomach longer It affects how your brain processes hunger and fullness signals These effects are central to how Mounjaro supports weight loss, but they can initially cause feelings of nausea as your body adapts to these changes