While 20% reduction in muscle mass seems normal for someone losing weight, the problem is the length of time in which this muscle loss occurs, said Kumar
Some mild side effects, such as nausea, bloating, or fatigue, can occur, but these are manageable with guidance from our team
*Correspondence: Qiyuan Keith Liu, [email protected]
How Common Is Muscle Loss with GLP-1/GIP Therapy
arthralgia incidence in trials is generally similar to placebo Rapid weight loss from GLP-1 treatment may alter biomechanical loading on joints, causing temporary adjustment-related discomfort Patients prescribed GLP-1 medications often have type 2 diabetes or obesity, conditions independently associated with increased osteoarthritis rates Seek medical advice for severe, worsening, or persistent joint pain, or if accompanied by swelling, redness, warmth, or systemic symptoms Report suspected medication side effects through the MHRA Yellow Card scheme to support ongoing safety monitoring Table of Contents Understanding GLP-1 Medications and Their Common Side Effects GLP-1 receptor agonists, including semaglutide (Ozempic, Wegovy) and liraglutide (Victoza, Saxenda), most commonly cause gastrointestinal side effects such as nausea, vomiting, and diarrhoea