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They found that microbial infections, such as SARS and H5N1 virus infections in the lungs, trigger NADPH-dependent ROS production, thereby generating oxidized phospholipids, such as oxidized 1-palmitoyl-2-arachidonoyl-sn-glycerol-3-phosphatidylcholine, to induce lung injury and cytokine production by lung macrophages via TLR4TRIF 80