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[DOI] [PubMed] [Google Scholar] 475.De R, Mahata MK, Kim KT

First, there is a need to clarify potential biological mechanisms by which incretin mimetics could directly lead to the development of PDAC

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In the SURMOUNT-1 study, a phase 3 clinical trial in obese patients, randomized participants in a 1:1:1:1 ratio to tirzepatide (5, 10, 15 mg) or placebo over 72 weeks, significant weight reductions were observed at 72 weeks: 15.0% for 5 mg, 19.5% for 10 mg, 20.9% for 15 mg, compared to 3.1% for placebo [18]