This is not an off-label stretch
Several mechanisms are thought to contribute, and these should be understood as hypotheses based on the drug's pharmacology and observations from related incretin-based therapies: Reduced caloric intake: Retatrutide significantly suppresses appetite, often leading to a substantial reduction in food consumption
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The negative effects produced by 1 mg/kg of WIN55,212-2 are hypothesized to be due to stronger reductions in Ca 2+ influx, resulting in reduced neuronal activity, which possibly hinders activity-dependent myelination (Tomas-Roig et al., 2020)