Palmitoylation is a reversible lipid modification where palmitate is covalently attached to cysteine residues through a thioester bond, which can significantly increase the hydrophobicity of proteins, thereby affecting their affinity for membrane structures, their membrane localization, protein-protein interactions, and signal transduction of the protein [60, 61]
Finally, small-molecule disruptors of protein aggregation, such as buntanetap and valiltramiprosate, are also in clinical tests
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