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At the level of precursor lesions such as nevi, the initial mutagenic events triggering the neoplastic transformation are represented by several mutations which lead to the activation of the MAPK pathway (such as BRAF V600E), while at an intermediate stage of tumour progression, NRAS and additional driver mutations are seen

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Cohort identification The background population of patients with diabetes mellitus was selected among Italian citizens residing in Veneto who had been eligible beneficiaries for at least 1 year between January 1st, 2011 and September 30th, 2018 or time of death