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NSAIDs exert their principal effects by inhibiting prostaglandin synthesis through cyclo-oxygenase (COX)-1 and COX-2 blockade

doi: 10.1016/j.jad.2019.07.035 155 FreemanMPHibbelnJRWisnerKLDavisJMMischoulonDPeetMet al

GHK binds copper because of a specific combination of functional groups that together form a high-affinity copper-coordination site: the N-terminal amine donates one nitrogen ligand, the histidine imidazole donates a second nitrogen ligand, and the deprotonated amide nitrogen of the Gly-His peptide bond donates a third nitrogen ligand

It transports long-chain fatty acids into the mitochondria so they can be oxidized to produce energy

Truong, J., Mailloux, R