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El espectro clnico es amplio, los signos que orientan al diagnstico son: hepatoesplenomegalia (generalmente con predominio de esplenomegalia), retraso en el desarrollo neurolgico y rasgos faciales toscos

As IGF-1R mAbs are already in clinical trials, these observations warrant further exploration into the possible development of these drugs for safe and effective long-term use in humans as a strategy to delay at least some manifestations of aging

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