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They had met at Lilly, where DiMarchi was the executive responsible for endocrine research

J Biol Chem (2013) 288(7):451321.10.1074/jbc.M112.402677 23 WangJHInoueTHigashiyamaMGuthPHEngelEKaunitzJDet alUmami receptor activation increases duodenal bicarbonate secretion via glucagon-like peptide-2 release in rats

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While researchers found that GLP-1 drugs collectively showed positive impact on managing type 2 diabetes by effectively lowering haemoglobin A1c and fasting plasma glucose levels, higher doses of these drugs were shown to significantly increase adverse gastrointestinal reactions

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