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JAK2 activation in BPC-157-treated tendon fibroblasts occurs in a time-dependent manner following growth hormone stimulation, indicating the peptide primes cells for enhanced growth factor responsiveness rather than directly activating the pathway in the absence of the endogenous ligand

[DOI] [PubMed] [Google Scholar] 73.Sattar N, Lee MM, Kristensen SL, Branch KR, Del Prato S, Khurmi NS, et al

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Klausen et al 37 reported adverse effects related to GI symptoms, body weight loss, fatigue, and injection site reactions, and the incidence was higher in the exenatide group compared with the placebo group