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In clinical trials of semaglutide injection for weight management, acute pancreatitis was confirmed by adjudication in 4 semaglutide-treated patients (0.2 cases per 100 patient-years) versus 1 in placebo-treated patients (less than 0.1 cases per 100 patient-years)

Lyophilized powder freezes fine for long-term storage, but once a peptide is in solution, ice crystals physically damage the structure you lose potency and get precipitation on thaw

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