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Weeks 12: 2 mg once weekly Weeks 36: 4 mg once weekly Weeks 710: 8 mg once weekly Week 11+: 12 mg once weekly (if tolerated) Fast escalation: Select cases, monitored closely This fast-escalation schedule is used only in specific situations where close supervision is available, such as in specialty clinics or structured clinical trial settings that follow strict safety protocols

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Retatrutide appears to be more effective than earlier medications because it addresses more of the biology driving obesity at once, says Dr