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6 Coincidentally, downregulated Sirtuin 3 (Sirt3)-mediated hyperacetylation of PDHA1 promotes the lactylation of mitochondrial fission 1 protein (Fis1) at K20 by increasing lactate overproduction in renal tubular epithelial cells, resulting in excessive mitochondrial injury
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Gazzetta Medica Italiana Archivio per le ScienzeMediche.1993;152(4): 117-120 Calabrese C, Tosco A, Abete P
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