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A well-documented chronology strengthens causation arguments significantly

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That therapeutic effect is because increased melanin production in the hypodermis layer absorbs UVB light rays, thus preventing skin irritation, damage, and early aging

Structures of active receptors reveal peptide agonists engage deep within the receptor core, leading to an outward movement of extracellular loop 3 and the tops of transmembrane helices 6 and 7, an inward movement of transmembrane helix 1, reorganization of extracellular loop 2 and outward movement of the intracellular side of transmembrane helix 6, resulting in G-protein interaction and activation 2,3,4,5,6