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Description

In the LPC demyelinating model, different phenotypes predominate at different stages of demyelination/remyelination, with an initial proinflammatory signature at the time of OPC recruitment, followed by a shift to a more regenerative state during remyelination (Miron et al., 2013)

489,496 Thirdly, NMNAT1 does not change the NAD + biosynthesis, but prevents the SARM1-dependent NAD + depletion caused by injury, which is important for axon degeneration