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As a chronic, multifactorial disease, obesity warrants the same clinical rigor in diagnosis, monitoring, and treatment as other chronic conditions such as dyslipidemia or type 2 diabetes mellitus ( Our findings support the consideration of pharmacological therapy as a component of pediatric obesity management when lifestyle interventions alone fail to achieve clinically meaningful outcomes

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Biomed Pharmacother 137:111285

Rosiglitazone, a widely prescribed TZD, faced scrutiny due to studies suggesting an increased risk of cardiovascular events, leading to regulatory restrictions on its use (363)