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studied the efficacy and safety of IV GSH for skin tone lightening in 25 patients of Pakistani origin in a placebo-controlled trial (1,200 mg given IV twice a week for 6 weeks in the treatment group versus normal saline in control group) [15]

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Typical dosing range: 200-1000 mcg subcutaneously, five nights on/two nights off, with initial dosing for females often starting at 0.1-0.3 mg daily and adjusted based on individual response and lab findings