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Beyond regulating V-ATPase activity through assembly, zinc enhances expression of V-ATPase subunits, at least in part via activation of the transcription factor TFEB

Both NF-B signaling and mtROS promote NLPR3 inflammasome assembly, a key driver of neuroinflammation that leads to cleavage of precursor cytokines into biologically active pro-inflammatory cytokines, IL-1 and IL-18 (Blevins et al., 2022)

R., Russell, R

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Studies indicated that atopic dermatitis is the cutaneous manifestation of systemic immune dysregulation, a type 2 immune response which is characterized by the predominance of Th2 cells over Th1 cells (Roesner et al