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10.1007/s00438-004-0986-8 101 PastoriG

Second, a 1:x (with x = 35) diluted sample of 13 C/ 15 N labeled monomers mixed with unlabeled ( 13 C/ 15 N at natural abundance) monomers greatly reduce the inter-monomeric contribution, thus allowing the unambiguous gathering of intra-molecular interactions (Wasmer et al., 2008)

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75 For instance, the simultaneous blockade of NMDA receptors alongside acetylcholinesterase inhibition has demonstrated synergistic neuroprotective effects in experimental models of AD, suggesting a complementary mechanism of action that could translate into improved cognitive outcomes in patients