The effect was modest compared to prescription medications but consistent and reproducible
Pharmacological activation of AMPK by administration of 5-aminoimidazole-4-carboxamide-1--dribofuranoside (AICAR) in either the 3rd [714] or the 4th ventricle [706] attenuates the anorectic effect of exendin-4 injected into the same ventricles
Total Impact: Taken together, we estimate that the changes in submissions due to policy provisions ( and newly available data will result in a change of +399 submissions (810 submissions due to policy provisions + 1,209 submissions due to updated data), an annual burden change of +3,624 hours (7,357.23 hr due to policy provisions + 10,981.35 hr due to updated data, rounded to the hour) at a cost of +$444,109 ($901,575.18 due to policy provisions + $1,345,684.44 due to updated data, rounded to the dollar)
Synthesis of Results This study presents data in a narrative form due to heterogeneity of the included literature not facilitating meta-analysis
Chadda KR, Cheng TS, Ong KK
